Tylenol typically starts working in 45 minutes after taking the tablets. Tylenol is a fast acting product, and typically the pain relieving effects last from 3-6 hours, depending on the person.

It is generally considered safe to take Tylenol and ibuprofen, such as Advil, together. This is because the active ingredients of both Tylenol and Advil are different, and can usually be used together to provide pain relief. If you find the combination of Tylenol and and ibuprofen is not enough to relieve your muscle or joint pains, you can also consider using a topical pain relief product like MEDISTIK to extend the effects of pain relief. Always consult a medical professional when developing a treatment plan or layering medications.

Tylenol can be taken on an empty stomach, according to many experts, as the active ingredient of Tylenol (acetaminophen) is thought to be much gentler on the stomach than other pain relieving products like Advil. You may take a Tylenol tablet with a glass of water, or by itself depending on your personal preference.

Tylenol typically lasts from 3-6 hours, though the effects will vary between people. Once the Tylenol has worn off, you may take another tablet providing it is more than 6 hours later and you have not met your maximum daily dosage. If unsure, consult a medical professional for more advice about dosage.

The difference between regular Tylenol and Tylenol Arthritis is the medication mechanism. Regular Tylenol is ingested and provides a dose of medication, but Tylenol Arthritis has a special bi-layer design, the first layer dissolves fast and the second lasts up to 8 hours to ease minor arthritis pain, as per Tylenol’s website.