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What is the Best Painkiller for Knee Pain?: Ask The Experts

July 15, 2025·By Chandni Handa·3 min read
Person holding knee in pain — expert advice on the best painkillers and treatments for knee pain at home.

TL;DR: What is the Best Painkiller for Knee Pain - Knee Pain Treatment at Home?

The best painkiller for knee pain will depend on the cause of the pain or injury. Effective knee pain treatment at home involves topical treatments like MEDISTIK, prioritizing targeted exercise, and reserving medications like NSAIDs for short-term use only.

What is Knee Pain?

Knee pain refers to the pain or discomfort you may feel in or around your knee area. You may experience pain in the back of your knee, or elsewhere and the severity of the knee pain may vary depending on the cause.

Symptoms of knee pain include:

  • Swelling

  • Stiffness

  • Weakness

  • Popping or crunching noises

  • Redness

  • Inability to straighten the knee

What is the Best Painkiller for Knee Pain: Expert Advice

So how do you treat knee pain at home, and what is the best painkiller for knee pain? We asked the experts.

Dr Liisa explains that the best painkiller depends on the cause of the pain and the severity of the injury. “The best painkiller will depend on the cause of your knee pain. Some people will seek out NSAIDS or other medical interventions, and treatments such as ultrasound, interferential current, and acupuncture can be great options. For home care, topical creams such as MEDISTIK can be a terrific alternative to medication.”

Dr. Liisa says topical creams like MEDISTIK are a great at-home option for knee pain relief.


Dr Matt agrees, and says that in many cases exercise might be the best painkiller for knee pain treatment at home:
“While often not at the forefront of people's minds when it comes to providing pain relief for an injury, exercise in various forms can provide regular, mild-to-moderate pain relief for an injury. 

Targeted exercises for muscle groups, depending on the injury and functional deficits observed, can also help attenuate load on the knee joint (i.e. hip abductor and quad strengthening for patellofemoral pain syndrome) or soft tissue overload (i.e. IT band syndrome).”

He goes on to say, “While there is a time and a place for medications, in most situations, non-pharmacological interventions should be attempted first. If medications such as NSAIDs are used, they should be for a short duration only. In addition to potential side effects impacting the liver, kidney, and stomach, prolonged medication use may have unfavorable effects on the injury site.” 

His preference? To prescribe exercises for the particular injury and “use topicals like MEDISTIK to avoid the systemic effects of oral medications while providing a window of local pain relief, so people can resume activity and improve function of the injury site.”

As to how to relieve leg or knee pain at night, Dr Liisa adds, “If you are a back sleeper, try placing a pillow under the knees, and if you prefer side sleeping, place a pillow in between your knees”.

Read more: how to start working out again after a knee injury

Key takeaways for What is the Best Painkiller for Knee Pain

If you’re wondering what the best painkiller for knee pain is, or how to treat knee pain at home, our experts shared this advice:

  • Choose pain relief based on the cause and severity

  • Exercise is often the most effective long-term solution

  • Treat your knee pain at home with topical treatments rather than NSAIDs

Infographic: Best painkillers for knee pain at home — use topicals, try targeted exercise, limit NSAID use.

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